The best way to fights spots using Freederm Gel Nicotinamide. Freederm Gel is an anti-inflammatory spot treatment containing the active ingredient nicotinamide, which has been clinically proven to help get rid of inflamed red spots - these are the ones that are reddish-colored, usually tender, and sometimes have pus in them. Freederm Gel works in a different way to other spot treatments you can buy, thanks to its anti-inflammatory action. It targets inflamed spots and pimples to help reduce redness and spot size. The unique formulation can even help stop spots that are just starting to form. And thanks to its special hydro-gel formulation, you'll find that Freederm Gel is less drying than some spot or acne treatments.